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The two most challenging groups of patients with whom to discuss fertility preservation are probably the patients whose tumors are ER positive, as the induction of amenorrhea has been associated with better breast cancer related outcomes, and patients with a genetic predisposition to ovarian cancer, such as women with mutations in BRCA1 BRCA2 or with Lynch syndrome hereditary nonpolyposis colorectal cancer HNPCC genes dapoxetine for premature Yr n 1 Design Treatment Conclusion Loprinzi et al 119 1997 45 A double blind, crossover, randomized clinical trial Vaginal lubricating preparation, Replens Both Replens and the placebo appear to substantially ameliorate vaginal dryness and dyspareunia in breast cancer survivors Lee et al 129 2011 44 vs 42 Randomised controlled trial, double blinded pH balanced gel vs placebo for 12 wk Vaginal pH balanced gel could relieve vaginal symptoms Juraskova et al 137 2013 25 Prospective, observational study polycarbophil based vaginal moisturizer olive oil as a lubricant during intercourse Significant improvements in dyspareunia, sexual function, and quality of life over time Goetsch et al 130, 131 2014 2015 46 Double blind rct 4 aqueous lidocaine vs saline Significative and safe reduction in dyspareunia Hickey et al 128 2016 In a single center, randomized, double blind, ab ba crossover design Water vs silicone based lubricants Total sexual discomfort was lower after use of silicone based lubricant than water based Juliato et al 126 2017 25 vs 25 Randomised trial Polyacrylic acid vs lubricant Polyacrylic acid was superior to lubricant Marschalek et al 136 2017 11 vs 11 Randomised controlled trial, double blinded pilot study Vaginal lactobacillus capsules vs placebo Lactobacillus improves microbiota in BCSs Hersant et al 139 2018 20 Prospective, comparative before after pilot study A PRP and evaluated at 0, 1, 3 and 6 mo A PRP improves vaginal mucosa in 6 mo treatment according VHI criteria Chatsiproios et al 125 2019 128 Open, prospective, multicentre, observational study
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