Премиум база для Xrumer
- Detta ämne är tomt.
- Inlägg
Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
[url=https://seoseed.ru/hermes-management-ltd-realnye-otzyvy-o-hermes-ltd-com/]русский анальный секс[/url]Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.
Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.
The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.
Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.
“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”
Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.Within a day or two of birth, the authors collected the babies’ blood via a heel stick.
The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.
Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.
Arctic auroras
[url=https://efhenna.net]ethena[/url]
For getting around during winter, the Inuit here nowadays prefer snowmobiles, although they still keep their sled dogs. During winter they’ll offer intrepid visitors, wrapped up warm against the deep-freeze temperatures, dog-sledding jaunts. These can last either an hour or be part of expeditions over several days, sometimes with the added experience of learning how to build an igloo. Sisimiut on the west coast and Tasilaq in the southeast are active winter centers for dog sledding.Winter’s most stellar attraction, though, is northern lights watching. With little urban light pollution, Greenland is a dark canvas for spectacular displays, and aurora borealis-watching vacations are becoming more popular.
Staying outdoors, Greenland is developing a reputation among adventure enthusiasts: from long-distance skiing expeditions and heliskiing on the icecap to hiking the 100-mile-long Arctic Circle Trail from Kangerslussuaq, where firearms need to be carried for warning shots in case of polar bear encounters.
Life is definitely changing here. The climate crisis is eating away at its icecap and Greenland may well end up as a pawn in a game of geopolitical chess. But for now, the bright glare of international attention should shine a favorable light on one of the wildest travel destinations on Earth.
Travel writer Mark Stratton is an Arctic specialist who has traveled to Greenland six times and counting. He’s marveled at the aurora borealis, sailed to Disko Island, dog-sledded with the Inuit, and once got stuck in an icefloe.
Tesla is bringing its electric cars to oil-rich Saudi Arabia amid falling global sales
[url=https://apepturefirmance.fi]aperture finance[/url]
Tesla will start selling its electric vehicles in Saudi Arabia, entering the Gulf region’s largest economy as the company’s global sales are sliding and CEO Elon Musk courts controversy with his role in the US government.The carmaker announced Wednesday that it would host a launch event in the kingdom on April 10, where it will showcase its EVs. Attendees will also have the chance to “experience the future of autonomous driving with Cybercab and meet Optimus, our humanoid robot, as we showcase what’s next in AI and robotics,” Tesla (TSLA) said.
Tesla may struggle to gain market share in oil-rich Saudi Arabia as EVs make up a little over 1% of all car sales in the country, according to a report by consultancy PwC published in September.
Tesla’s entry into the new market comes as the company fights battles on several fronts.Last year, it recorded the first annual decline in sales in its history as a public company, posting a drop of 1%.
The company is facing intensifying competition in China, the world’s largest auto market. On Tuesday, BYD, a Chinese maker of electric and hybrid cars, reported $107 billion in annual sales for 2024, beating the near-$98 billion notched by Tesla.
And last week, BYD unveiled an ultra-fast charging system, which it said was capable of adding 250 miles (402 km) of range in just five minutes, easily outdoing Tesla’s charging technology. Tesla’s Superchargers take 15 minutes to charge an EV, providing a range of 200 miles.
Tesla has also suffered slumping sales in Europe. In February, the carmaker sold around 40% fewer vehicles on the continent compared with the same month in 2024, according to the European Automobile Manufacturers’ Association.
