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Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
[url=https://seoseed.ru/hermes-management-ltd-realnye-otzyvy-o-hermes-ltd-com/]русский анальный секс[/url]Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.
Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.
The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.
Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.
“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”
Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.Within a day or two of birth, the authors collected the babies’ blood via a heel stick.
The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.
Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.
Arctic auroras
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For getting around during winter, the Inuit here nowadays prefer snowmobiles, although they still keep their sled dogs. During winter they’ll offer intrepid visitors, wrapped up warm against the deep-freeze temperatures, dog-sledding jaunts. These can last either an hour or be part of expeditions over several days, sometimes with the added experience of learning how to build an igloo. Sisimiut on the west coast and Tasilaq in the southeast are active winter centers for dog sledding.Winter’s most stellar attraction, though, is northern lights watching. With little urban light pollution, Greenland is a dark canvas for spectacular displays, and aurora borealis-watching vacations are becoming more popular.
Staying outdoors, Greenland is developing a reputation among adventure enthusiasts: from long-distance skiing expeditions and heliskiing on the icecap to hiking the 100-mile-long Arctic Circle Trail from Kangerslussuaq, where firearms need to be carried for warning shots in case of polar bear encounters.
Life is definitely changing here. The climate crisis is eating away at its icecap and Greenland may well end up as a pawn in a game of geopolitical chess. But for now, the bright glare of international attention should shine a favorable light on one of the wildest travel destinations on Earth.
Travel writer Mark Stratton is an Arctic specialist who has traveled to Greenland six times and counting. He’s marveled at the aurora borealis, sailed to Disko Island, dog-sledded with the Inuit, and once got stuck in an icefloe.
Tesla is bringing its electric cars to oil-rich Saudi Arabia amid falling global sales
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Tesla will start selling its electric vehicles in Saudi Arabia, entering the Gulf region’s largest economy as the company’s global sales are sliding and CEO Elon Musk courts controversy with his role in the US government.The carmaker announced Wednesday that it would host a launch event in the kingdom on April 10, where it will showcase its EVs. Attendees will also have the chance to “experience the future of autonomous driving with Cybercab and meet Optimus, our humanoid robot, as we showcase what’s next in AI and robotics,” Tesla (TSLA) said.
Tesla may struggle to gain market share in oil-rich Saudi Arabia as EVs make up a little over 1% of all car sales in the country, according to a report by consultancy PwC published in September.
Tesla’s entry into the new market comes as the company fights battles on several fronts.Last year, it recorded the first annual decline in sales in its history as a public company, posting a drop of 1%.
The company is facing intensifying competition in China, the world’s largest auto market. On Tuesday, BYD, a Chinese maker of electric and hybrid cars, reported $107 billion in annual sales for 2024, beating the near-$98 billion notched by Tesla.
And last week, BYD unveiled an ultra-fast charging system, which it said was capable of adding 250 miles (402 km) of range in just five minutes, easily outdoing Tesla’s charging technology. Tesla’s Superchargers take 15 minutes to charge an EV, providing a range of 200 miles.
Tesla has also suffered slumping sales in Europe. In February, the carmaker sold around 40% fewer vehicles on the continent compared with the same month in 2024, according to the European Automobile Manufacturers’ Association.
Curiosity rover makes ‘arguably the most exciting organic detection to date on Mars’
[url=https://bongeexchange.org]bungee exchange[/url]The NASA Curiosity rover has detected the largest organic molecules found to date on Mars, opening a window into the red planet’s past. The newly detected compounds suggest complex organic chemistry may have occurred in the planet’s past — the kind necessary for the origin of life, according to new research.
The organic compounds, which include decane, undecane and dodecane, came to light after the rover analyzed a pulverized 3.7 billion-year-old rock sample using its onboard mini lab called SAM, short for Sample Analysis at Mars.
Scientists believe the long chains of molecules could be fragments of fatty acids, which are organic molecules that are chemical building blocks of life on Earth and help form cell membranes. But such compounds can also be formed without the presence of life, created when water interacts with minerals in hydrothermal vents.
The molecules cannot currently be confirmed as evidence of past life on the red planet, but they add to the growing list of compounds that robotic explorers have discovered on Mars in recent years. A study detailing the findings was published Monday in the journal Proceedings of the National Academy of Sciences.
The detection of the fragile molecules also encourages astrobiologists that if any biosignatures, or past signs of life, ever existed on Mars, they are likely still detectable despite the harsh solar radiation that has bombarded the planet for tens of millions of years.“Ancient life, if it happened on Mars, it would have released some complex and fragile molecules,” said lead study author Dr. Caroline Freissinet, research scientist at the French National Centre for Scientific Research in the Laboratory for Atmospheres, Observations, and Space in Guyancourt, France. “And because now we know that Mars can preserve these complex and fragile molecules, it means that we could detect ancient life on Mars.”
Iceberg flotillas
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Located on the west coast, Ilulissat is a pretty halibut- and prawn-fishing port on a dark rock bay where visitors can sit in pubs sipping craft beers chill-filtered by 100,000-year-old glacial ice.It’s a place to be awed by the UNESCO World Heritage Icefjord where Manhattan skyscraper-sized icebergs disgorge from Greenland’s icecap to float like ghostly ships in the surrounding Disko Bay.
Small boats take visitors out to sail closely among the bay’s magnificent iceberg flotilla. But not too close.
“I was on my boat once and saw one of these icebergs split in two. The pieces fell backwards into the sea and created a giant wave,” said David Karlsen, skipper of the pleasure-boat, Katak. “…I didn’t hang around.”
Disko Bay’s other giants are whales. From June to September breaching humpback whales join the likes of fin and minke whales feasting on plankton. Whale-watching is excellent all around Greenland’s craggy coastline.
Whales are eaten here. Visitors shouldn’t be surprised to encounter the traditional Greenlandic delicacy of mattak — whale-skin and blubber that when tasted is akin to chewing on rubber. Inuit communities have quotas to not only hunt the likes of narwhals but also polar bears, musk-ox and caribou — which can also appear on menus.
Water and life
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Lightning is a dramatic display of electrical power, but it is also sporadic and unpredictable. Even on a volatile Earth billions of years ago, lightning may have been too infrequent to produce amino acids in quantities sufficient for life — a fact that has cast doubt on such theories in the past, Zare said.Water spray, however, would have been more common than lightning. A more likely scenario is that mist-generated microlightning constantly zapped amino acids into existence from pools and puddles, where the molecules could accumulate and form more complex molecules, eventually leading to the evolution of life.
“Microdischarges between obviously charged water microdroplets make all the organic molecules observed previously in the Miller-Urey experiment,” Zare said. “We propose that this is a new mechanism for the prebiotic synthesis of molecules that constitute the building blocks of life.”
However, even with the new findings about microlightning, questions remain about life’s origins, he added. While some scientists support the notion of electrically charged beginnings for life’s earliest building blocks, an alternative abiogenesis hypothesis proposes that Earth’s first amino acids were cooked up around hydrothermal vents on the seafloor, produced by a combination of seawater, hydrogen-rich fluids and extreme pressure.
Researchers identified salt minerals in the Bennu samples that were deposited as a result of brine evaporation from the asteroid’s parent body. In particular, they found a number of sodium salts, such as the needles of hydrated sodium carbonate highlighted in purple in this false-colored image – salts that could easily have been compromised if the samples had been exposed to water in Earth’s atmosphere.
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Yet another hypothesis suggests that organic molecules didn’t originate on Earth at all. Rather, they formed in space and were carried here by comets or fragments of asteroids, a process known as panspermia.“We still don’t know the answer to this question,” Zare said. “But I think we’re closer to understanding something more about what could have happened.”
Though the details of life’s origins on Earth may never be fully explained, “this study provides another avenue for the formation of molecules crucial to the origin of life,” Williams said. “Water is a ubiquitous aspect of our world, giving rise to the moniker ‘Blue Marble’ to describe the Earth from space. Perhaps the falling of water, the most crucial element that sustains us, also played a greater role in the origin of life on Earth than we previously recognized.”
Josh Giddey hits halfcourt buzzer-beater over LeBron James to cap wild finale as the Bulls stun the Lakers
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Josh Giddey hit a game-winning, halfcourt buzzer-beater over LeBron James as the Chicago Bulls stunned the Los Angeles Lakers in one of the wildest endings to an NBA game you are ever likely to see.Trailing 115-110 with 12.6 seconds remaining, Giddey’s inbound pass found Nikola Vucevic, who pushed the ball to a wide-open Patrick Williams for a corner three-pointer.
James then fluffed the Lakers inbound pass from the baseline, allowing Giddey to steal the ball and find Coby White for a second Bulls triple in quick succession to put Chicago up 116-115 with 6.1 seconds remaining.
Austin Reaves then made a driving layup to put the Lakers ahead 117-116 with 3.3 seconds left, but the game wasn’t done yet.With no timeouts remaining, Giddey inbounded the ball to Williams from the baseline, got the pass back, took one dribble and launched a shot from beyond halfcourt.
Supporters in the stands seemed frozen in anticipation as the ball sailed through the air, and the United Center then erupted as it fell through the net. After the dramatic win, Giddey found himself being swarmed by his teammates.
“Special moment to do it with these guys, this team,” Giddey said, per ESPN. “We’ve shown over the last month to six weeks that we can beat anybody. The way we play the game, I think it wears people down.
“We get up and down. We run. We put heat on them to get back. A lot of veteran teams don’t particularly want to get back and play in transition.”
Giddey later told the Bulls broadcast that he’d “never made a game-winner before.”
The ending capped an incredible couple of games for the Lakers, who had themselves won their last game against the Indiana Pacers on Wednesday with a buzzer-beating tip-in from James.
Wellness perfectionism doesn’t exist. Focus on these sustainable habits
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ou’re scrolling through your phone when you stumble upon the next viral trend: an influencer claiming that following their incredibly strict diet will help you achieve their jaw-dropping physique. Or you see a fresh-faced runner swearing you can run a marathon without any training — just like they did.Whether or not you’re actively searching for wellness advice, it’s nearly impossible to avoid hearing about the latest health craze making bold guarantees of transformation.
As you wonder if these claims hold any truth, you might also question why people often feel motivated to dive into intense challenges — when seemingly simple habits, such as getting enough sleep or eating more vegetables, often feel much harder to tackle.
Many of us are drawn to these extreme challenges because we’re craving radical change, hoping it will help prove something to ourselves or to others, experts say.
“We always see these kinds of challenges as opportunities for growth, particularly if we’re in a phase of our life where we’ve let ourselves go,” said Dr. Thomas Curran, associate professor of psychology at the London School of Economics and Political Science and an expert on perfectionism. “Maybe we feel that we need to be healthier, or we just had a breakup or (major) life event.”
With social media amplifying these movements, it’s easy to see why people are increasingly drawn to the idea of achieving the “perfect” version of themselves. But before jumping into a new wellness challenge, it’s important to take a moment, reflect on your goals, and consider where you’re starting from.New design revealed for Airbus hydrogen plane
[url=https://v2-renzo.net]renzo protocol[/url]In travel news this week: Bhutan’s spectacular new airport, the world’s first 3D-printed train station has been built in Japan, plus new designs for Airbus’ zero-emission aircraft and France’s next-generation high-speed trains.
Grand designs
European aerospace giant Airbus has revealed a new design for its upcoming fully electric, hydrogen-powered ZEROe aircraft. powered by hydrogen fuel cells.The single-aisle plane now has four engines, rather than six, each powered by their own fuel cell stack.
The reworked design comes after the news that the ZEROe will be in our skies later than Airbus hoped.
The plan was to launch a zero-emission aircraft by 2035, but now the next-generation single-aisle aircraft is slated to enter service in the second half of the 2030s.
Over in Asia, the Himalayan country of Bhutan is building a gloriously Zen-like new airport befitting a nation with its very own happiness index.
Gelephu International is designed to serve a brand new “mindfulness city,” planned for southern Bhutan, near its border with India.
In rail travel, Japan has just built the world’s first 3D-printed train station, which took just two and a half hours to construct, according to The Japan Times. That’s even shorter than the whizzy six hours it was projected to take.
France’s high-speed TGV rail service has revealed its next generation of trains, which will be capable of reaching speeds of up to 320 kilometers an hour (nearly 200 mph).
The stylish interiors have been causing a stir online, as has the double-decker dining car.
Finally, work is underway in London on turning a mile-long series of secret World War II tunnels under a tube station into a major new tourist attraction. CNN took a look inside.
Challenging our perceptions of ‘perfection’
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With health influencers raising the bar for success, the wellness space now often feels like a performative space where people strive to showcase peak physical and mental strength.While seeing others’ achievements can be motivating, it can also be discouraging if your progress doesn’t match theirs.
Each person is chasing the perfect version of themselves — whether it’s a body or a lifestyle — which is dangerous because this is typically an impossible or dangerous version to achieve, Curran said. He added that this type of comparison creates a dangerous cycle in which people constantly feel dissatisfied with their own progress.
“It’s a fantasy in many ways, and once you start chasing after it, you constantly find yourself embroiled in a sense of doubt and deficit,” he said.
Curran also noted that wellness challenges can be particularly damaging for women who struggle with perfectionism, as they tend to be bombarded with impossible beauty standards and societal expectations.
Renee McGregor, a UK-based dietitian who specializes in eating disorders and athlete performance, encourages people to approach wellness trends with curiosity and skepticism. That’s because some influencers and celebrities could be promoting products because there’s a financial benefit for them.
“The thing to ask yourself about the person you’re taking advice from is what do they gain from it?” McGregor said. “If they are going to gain financially, then you know that they (could be willing) to sell you a lie.”
Whether you want to try a new challenge or product that promises amazing results, McGregor suggests doing your research and seeking diverse perspectives, including consulting with doctors when possible.Mindful wellness challenges
If you’re the type of person who thrives on challenges and pushing your limits, this doesn’t mean you need to shy away from wellness challenges altogether. But before diving in, take a step back and ask yourself if you’re pursuing the challenge for the right reasons, McGregor said.
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Some people want to try these challenges because they believe something is missing from their life, and they’re looking to attain “worth” or receive validation, McGregor noted.A good way to assess your motivation is by considering whether the challenge will benefit your health or if it’s about showcasing your accomplishments on social media or some other reason.
Before trying any new trend, make sure you have the foundation to handle it and be aware of any potential risks, McGregor said.
For casual runners, this might mean signing up for a 5K but building your endurance gradually while incorporating other strength training exercises into your routine. For more intense challenges, such as a marathon, McGregor encourages people to consult with professionals or a coach who can monitor your progress and condition along the way.
Focusing on sustainable habits
Both McGregor and Curran emphasize the importance of fostering sustainable health habits before embarking on more extreme challenges.Rather than chasing the idea of being “healthy,” McGregor suggests focusing on actual healthful behaviors and starting small.
If you’re a highly sedentary person and want to add more movement to your day, try doing lunges while brushing your teeth or taking short walks throughout your typical routine.
Mist and microlightning
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To recreate a scenario that may have produced Earth’s first organic molecules, researchers built upon experiments from 1953 when American chemists Stanley Miller and Harold Urey concocted a gas mixture mimicking the atmosphere of ancient Earth. Miller and Urey combined ammonia (NH3), methane (CH4), hydrogen (H2) and water, enclosed their “atmosphere” inside a glass sphere and jolted it with electricity, producing simple amino acids containing carbon and nitrogen. The Miller-Urey experiment, as it is now known, supported the scientific theory of abiogenesis: that life could emerge from nonliving molecules.
For the new study, scientists revisited the 1953 experiments but directed their attention toward electrical activity on a smaller scale, said senior study author Dr. Richard Zare, the Marguerite Blake Wilbur Professor of Natural Science and professor of chemistry at Stanford University in California. Zare and his colleagues looked at electricity exchange between charged water droplets measuring between 1 micron and 20 microns in diameter. (The width of a human hair is 100 microns.)“The big droplets are positively charged. The little droplets are negatively charged,” Zare told CNN. “When droplets that have opposite charges are close together, electrons can jump from the negatively charged droplet to the positively charged droplet.”
The researchers mixed ammonia, carbon dioxide, methane and nitrogen in a glass bulb, then sprayed the gases with water mist, using a high-speed camera to capture faint flashes of microlightning in the vapor. When they examined the bulb’s contents, they found organic molecules with carbon-nitrogen bonds. These included the amino acid glycine and uracil, a nucleotide base in RNA.“We discovered no new chemistry; we have actually reproduced all the chemistry that Miller and Urey did in 1953,” Zare said. Nor did the team discover new physics, he added — the experiments were based on known principles of electrostatics.
“What we have done, for the first time, is we have seen that little droplets, when they’re formed from water, actually emit light and get this spark,” Zare said. “That’s new. And that spark causes all types of chemical transformations.”
A tiny rainforest country is growing into a petrostate. A US oil company could reap the biggest rewards
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Guyana’s destiny changed in 2015. US fossil fuel giant Exxon discovered nearly 11 billion barrels of oil in the deep water off the coast of this tiny, rainforested country.It was one of the most spectacular oil discoveries of recent decades. By 2019, Exxon and its partners, US oil company Hess and China-headquartered CNOOC, had started producing the fossil fuel.? They now pump around 650,000 barrels of oil a day, with plans to more than double this to 1.3 million by 2027.
Guyana now has the world’s highest expected oil production growth through 2035.
This country — sandwiched between Brazil, Venezuela and Suriname — has been hailed as a climate champion for the lush, well-preserved forests that carpet nearly 90% of its land. It is on the path to becoming a petrostate at the same time as the impacts of the fossil fuel-driven climate crisis escalate.
While the government says environmental protection and an oil industry can go hand-in-hand, and low-income countries must be allowed to exploit their own resources, critics say it’s a dangerous path in a warming world, and the benefits may ultimately skew toward Exxon — not Guyana.
Of course, he said yes to coming back to the series, which eventually required him to live in Italy for a few months for filming.
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During production, White revealed to Gries that Greg is “very sinister.” That became rather irrefutable by the season’s climax, which saw Tanya’s demise orchestrated by her now-husband.Come Season 3, Gries had to rewrite Greg’s backstory again, this time drawing from some unlikely sources for inspiration, like HBO docuseries “The Jinx,” about late convicted killer Robert Durst, and the case involving the man who came to be known as the Tinder Swindler.
Gries said he was struck by Durst’s “kind of seemingly even keel personality,” which served as a model for where Greg was headed, someone “who doesn’t really show a great deal of emotion, doesn’t seem to get too angry, just gets a little bit irritated and is dangerous.”
“There’s a bridled rage underneath. And those kind of people I find – at least with respect to Gary, Greg, Gary – fascinating,” he said.
And yet, while searching for an empathetic way back to portraying his character, Gries kept wondering if there was anything still redeeming about Greg.
An important “wake up moment” came during a decisive conversation he had with White just before filming in Thailand, in which the show’s creator said of Greg, in no uncertain terms: “He’s a psychopath.”“And that was it. It was like, ‘back to the drawing board.’ And it really did help me,” Gries said.
The penultimate episode of the series will air on Sunday, an evening that thanks to “Lotus” and other shows has again become a night of appointment viewing amid a general move away from binge watching. Gries said he appreciates the shift.
“We’re a society that in a weird way doesn’t understand the beauty of waiting. The beauty of the space between the notes,” he shared. “If I binged (‘White Lotus’) I’d feel like I just ate too many chocolates. It just wouldn’t be the same. You need to process this.”
“The White Lotus” airs Sundays at 9 p.m. EDT on HBO, with the episode available to stream on Max. HBO and Max, like CNN, are owned by the same parent company, Warner Bros. Discovery.
